Does it matter which drive-by-wire pedal I use with an LS DBW throttle body?

Here is what the documentation says. Each point links to its source; details depend on your exact computer, harness and transmission.

• LSx: Holley's Terminator X Max supports GM pedal 10379038 with LSx throttle bodies 12570790 (6-pin), 12570800 (8-pin), 12580195 (8-pin), 12580760 (6-pin), 12605109 (6-pin), and 12629992 (6-pin). (Holley)
• 0411, 242/P59; LS1, LS6, LM7, LQ4, LQ9, LM4, L59; 1997-2007: All factory 24x-reluctor DBW LS engines used a separate throttle actuator control (TAC) module installed between the engine harness and the throttle pedal via a TAC sub-harness; it establishes communication between the pedal, the PCM, and the throttle body. (LSX Magazine (Power Automedia))
• 0411, 242; 1997-2007: The early all-plastic TAC module pairs only with the 411 PCM (red/blue connectors), while the later plastic-body TAC with metal mounting brackets pairs only with the 242 PCM (green/blue connectors); the two TAC modules are not interchangeable. (LSX Magazine (Power Automedia))
• 0411, 242; 1999-2007: Identify a 411 PCM versus a 242 PCM by connector colors: red and blue connections on the 411, green and blue on the 242. (LSX Magazine (Power Automedia))
• 0411, 242; 1997-2007: The early all-plastic TAC module is found on 1997-2004 C5 Corvettes, 2004-2005 CTS-Vs, and 2001-2002 full-size SUVs; the later TAC with metal brackets is found on 2003-2007 body-style trucks and SUVs. (LSX Magazine (Power Automedia))
• 0411, 242; 1997-2007: The throttle pedal and the TAC module sub-harness must be compatible, otherwise there is no control over the LS; mixing the similar-looking C5 and truck pedal connectors causes hard-to-diagnose throttle issues. (LSX Magazine (Power Automedia))
• 0411, 242; 1997-2007: Yes, pedal choice matters: the Gen III DBW pedal, TAC module, TAC sub-harness, throttle body, and PCM must all belong to the same family (early all-plastic TAC with the 411 red/blue PCM, or late metal-bracket TAC with the 242 green/blue PCM); mixing families causes hard-to-diagnose throttle failures. (LSX Magazine (Power Automedia))
• 242; 2003-2007: ACDelco 12588923 is cataloged as a throttle-control actuator module (TAC module) for selected 2003-2007 GM models. (Jegs)

Confirm against the instructions for your exact parts before wiring. More: Throttle (drive-by-wire) in our tuning guide.